Cass City is a village in Tuscola County in the Flint/Tri-Cities area of the U.S. state of Michigan. The population was 2,428 at the 2010 U.S. Census and 2,643 at the 2000 U.S. Census. It is located along M-81 approximately four miles west of that highway's intersection with M-53. Cass City is surrounded by several communities including Colwood, Deford, Elmwood and Ellington.